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pentobarbital will lower the level or influence of etoposide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital decreases consequences of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of CYP3A4 inducers may decrease sufentanil degrees